The academia have an ongoing debate about the choice of the optimal monetary intermediate target among interest rates, simplesum monetary aggregates and Divisia monetary aggregates. This paper compares empirically the relative importance of the overnight interbank interest rate R, simplesum monetary aggregate M2, Divisia monetary aggregate D2 to price P, output Y in the US, the euro zone and the UK respectively based on a DAGSVAR model. The results show that M2 has the largest impact on Y and R has the largest impact on P in the US. In the euro zone, D2 has the largest impact on Y and M2 has the largest impact on P. In the UK, M2 has the largest impact on both Y and P. In summary, if the monetary ultimate target is economic growth, the optimal intermediate targets of the US and the UK are simplesum monetary aggregates, the euro zones optimal intermediate target is the Divisia monetary aggregate. If the monetary ultimate target is price stability, the optimal intermediate target of the US is the interest rate, the optimal intermediate target of the euro zone and the UK are simplesum monetary aggregates. Thus, for different economies or monetary ultimate targets, the choice of the optimal intermediate target may be different. The conclusion of this paper is to some extent to the contradictory supplement of the academic consensus interest rates generally perform better than the monetary aggregates and Divisia monetary aggregates are generally perform better than simplesum monetary aggregates.